Findings in a new study suggest that CBD hemp oil can be beneficial for those who experience adverse effects following an HPV vaccination.
Cannabidiol (CBD) hemp oil can relieve symptoms and improve life quality in those with adverse effects following human papillomavirus (HPV) vaccination, suggest the findings in a new study published in the Israel Medical Association Journal. Researchers from the University of Modena and Reggio Emilia Medical School found CBD-rich hemp oil to be a promising treatment for severe somatoform and dysautonomic syndrome following HPV vaccination.
In the new open-label study, 12 females between the ages of 12 and 24 that had an adverse response to the HPV vaccination were given sublingual CBD hemp oil drops for three months. They were given 25 mg/kg per day, supplemented by 2-5 mg/ml CBD once a week until a maximum dose of 150 mg/ml CBD per day was reached.
CBD hemp oil is extracted from hemp plants that contain high concentrations of the non-psychoactive cannabinoid cannabidiol (CBD), and low concentrations of the psychoactive compound tetrahydrocannabinol (THC). Because hemp contains only trace levels of THC, CBD hemp oil products are non-psychoactive, meaning they don’t cause a high.
Researchers observed that the CBD hemp oil treatments caused “significant benefits in the physical component score, vitality and social role functioning.” It also significantly reduced body pain while causing no significant differences in role limitations due to emotional functioning.
“This study demonstrated the safety and tolerability of CBD-rich hemp oil and the primary efficacy endpoint,” the researchers concluded.
Two patients did withdraw early from the study because they experienced no benefit.
The Centers for Disease Control and Prevention (CDC) encourages parents to vaccinate their children for HPV around the ages of 11 or 12, before they’re susceptible to the most common sexually transmitted infection in the U.S. An estimated 79 million Americans are infected with HPV, which in some cases can be harmless but in others lead to cancer or genital warts.
In most cases, the HPV vaccination is effective at protecting from HPV and its related cancers while being well tolerated. In some cases, however, the vaccine can have serious side effects. In 2017, the World Health Organization (WHO) documented complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), dysautonomic syndrome, autonomic neuropathy, multiple system, and chronic fatigue as potential adverse effects of the vaccination.
The researchers suggested that the adverse effects following HPV vaccinations might be related to an imbalance in the body’s endocannabinoid system, a complex signaling network tasked with regulating a wide array of processes. They hypothesized that supplementing the endocannabinoid system, also referred to as the endogenous cannabinoid system, with plant-derived cannabinoids like CBD could stimulate the endocannabinoid system.
“Due to the absence of a safe and effective therapy for these girls who were living with their families and having to deal with difficult conditions (such as emotional instability, social problems as well as school obligations), and suspecting that an endogenous cannabinoid network imbalance might be responsible for some of the described symptoms, we selected a natural therapeutic approach based on CBD-enriched hemp oil over a 3 month period in our Italian cohort,” they wrote.
The new study suggests that CBD hemp oil may be beneficial for those cases in which adverse side effects develop, although the researchers did urge for blind clinical research to further investigate the oil’s efficacy.
The entire study, “Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination,” is available to access through the Israel Medical Association Journal.